Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4581668 | 1.00 | ADRB2 (0.40) | ADRB2ADRB1ADRB3PPARGPPARA | |
| SCHEMBL15058771 | 0.75 | PPARG (0.50) | ADRB2ADRB1ADRB3PPARGPPARA | |
| SCHEMBL2616111 | 0.70 | MAPK1 (0.56) | ADRB2ADRB1ADRB3POLBKMT2A | |
| SCHEMBL12546685 | 0.68 | ALDH1A1 (0.45) | ADRB2ADRB1ADRB3POLBKMT2A | |
| SCHEMBL15058988 | 0.68 | TDP1 (0.58) | POLBKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL5483822 | 0.67 | POLB (0.59) | ADRB2ADRB1ADRB3POLBKMT2A | |
| SCHEMBL8771998 | 0.67 | GAA (0.44) | SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8771877 | 0.67 | GAA (0.39) | KMT2AMEN1NR1H4LMNASMN1; SMN2 | |
| SCHEMBL7439793 | 0.66 | ALDH1A1 (0.31) | MAPTALDH1A1 | |
| SCHEMBL9987234 | 0.66 | TDP1 (0.61) | ADRB2ADRB1ADRB3POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751669-A4 | COMPUTATIONAL PROTEIN PROBING TO IDENTIFY BINDING SITES | SARNOFF CORP (US) | 2008-11-05 | — | — | EP | disclosed |
| EP-1912145-A2 | Computational protein probing to identify binding sites | Sarnoff Corporation (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1751669-A1 | COMPUTATIONAL PROTEIN PROBING TO IDENTIFY BINDING SITES | The Sarnoff Corporation (US) | 2007-02-14 | — | — | EP | disclosed |
| EP-1604319-A4 | COMPUTATIONAL PROTEIN PROBING TO IDENTIFY BINDING SITES | SARNOFF CORP (US) | 2006-08-02 | — | — | EP | disclosed |
| EP-1604319-A1 | COMPUTATIONAL PROTEIN PROBING TO IDENTIFY BINDING SITES | Sarnoff Corporation (US) | 2005-12-14 | — | — | EP | disclosed |
| WO-2005114458-A1 | COMPUTATIONAL PROTEIN PROBING TO IDENTIFY BINDING SITES | SARNOFF CORPORATION (US) | 2005-12-01 | — | — | WO | disclosed |
| WO-2004081841-A1 | COMPUTATIONAL PROTEIN PROBING TO IDENTIFY BINDING SITES | SARNOFF CORPORATION (US) | 2004-09-23 | — | — | WO | disclosed |