Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | IDH2 | P48735 | 1/20 | 0.30 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4581873 | 1.00 | PRMT5 (0.32) | PRMT5WDR77GPBAR1TRPV3PTGDR2 | |
| SCHEMBL4581881 | 1.00 | PRMT5 (0.32) | PRMT5WDR77GPBAR1TRPV3PTGDR2 | |
| SCHEMBL4582122 | 0.81 | HCRTR1 (0.33) | GPBAR1PTGDR2 | |
| SCHEMBL4582129 | 0.81 | HCRTR1 (0.33) | GPBAR1PTGDR2 | |
| SCHEMBL2784832 | 0.80 | CCR5 (0.31) | PTGDR2 | |
| SCHEMBL2784825 | 0.80 | CCR5 (0.31) | PTGDR2 | |
| SCHEMBL2784829 | 0.80 | CCR5 (0.31) | PTGDR2 | |
| SCHEMBL1596116 | 0.79 | GAA (0.39) | PRMT5WDR77PTGDR2IDH1IDH2 | |
| SCHEMBL1596122 | 0.79 | GAA (0.39) | PRMT5WDR77PTGDR2IDH1IDH2 | |
| SCHEMBL1596249 | 0.79 | GAA (0.39) | PRMT5WDR77PTGDR2IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509218-A4 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-03-26 | — | — | EP | disclosed |
| EP-1509218-A1 | PEPTIDE DEFORMYLASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003101442-A1 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-11 | — | — | WO | disclosed |