Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695257 | 0.83 | CYP19A1 (0.41) | KDRCHEK1RAB9AKDM4EMAPT | |
| SCHEMBL5051826 | 0.82 | KDR (0.68) | KDRCHEK1RAB9AKDM4EMAPT | |
| SCHEMBL9846713 | 0.82 | KDM4E (0.49) | RAB9AKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL28479668 | 0.82 | CYP19A1 (0.58) | CHEK1CYP19A1TRPA1 | |
| SCHEMBL28903107 | 0.82 | KDM4E (0.44) | KDRCHEK1RAB9AKDM4EMAPT | |
| SCHEMBL28485391 | 0.82 | PTGES (0.46) | KDRCHEK1RAB9AKDM4EMAPT | |
| Benzene SCHEMBL27629233 | 0.81 | RAB9A (0.69) | KDRCHEK1RAB9AKDM4EMAPT | |
| Methane SCHEMBL28704887 | 0.81 | KDR (0.66) | KDRCHEK1RAB9AKDM4EMAPT | |
| SCHEMBL6303491 | 0.79 | KDM4E (0.61) | KDRRAB9AKDM4EMAPTMEN1 | |
| SCHEMBL10176240 | 0.77 | KDR (0.61) | KDRCHEK1RAB9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-05-22 | — | — | US | claimed |
| WO-2008024978-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | claimed |
| CN-111793069-B | Method for efficiently preparing fused ring compound containing indole structural unit | 清华大学 | 2021-05-18 | — | — | CN | disclosed |
| CN-111793069-B | Method for efficiently preparing fused ring compound containing indole structural unit | 清华大学 | 2021-05-18 | — | — | CN | disclosed |
| CN-111793069-A | Method for efficiently preparing fused ring compound containing indole structural unit | 清华大学 | 2020-10-20 | — | — | CN | disclosed |
| CN-111793069-A | Method for efficiently preparing fused ring compound containing indole structural unit | 清华大学 | 2020-10-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | MKI67, CCNB1, RB1 | KDR 206/4885CHEK1 1637/4885RAB9A 3769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.