Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 14/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458097 | 0.89 | GRIN2B (0.57) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL24493183 | 0.83 | GRIN2B (0.55) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL30578289 | 0.83 | GRIN2B (0.55) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL13450952 | 0.82 | GRIN2B (0.71) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL9760056 | 0.82 | SMN1; SMN2 (0.59) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL18430337 | 0.80 | GRIN2B (0.74) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL15000907 | 0.80 | GRIN2B (0.65) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL6593704 | 0.80 | SMN1; SMN2 (0.56) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL34465709 | 0.80 | LTA4H (0.50) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL13168269 | 0.80 | SMN1; SMN2 (0.57) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |