Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.47 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.47 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20207185 | 0.89 | SMN1; SMN2 (0.57) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL13168269 | 0.89 | SMN1; SMN2 (0.57) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL13450952 | 0.88 | GRIN2B (0.71) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL13439706 | 0.88 | GRIN2B (0.61) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL6593704 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL3554740 | 0.84 | SIGMAR1 (0.57) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL13198831 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL7035676 | 0.83 | GRIN2B (0.58) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL9761065 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL458231 | 0.82 | GRIN2B (0.57) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |