Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582586 | 0.97 | KMT2A (0.50) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4582502 | 0.93 | KMT2A (0.48) | KMT2AMEN1LMNAALDH1A1MAPK1 | |
| SCHEMBL4582329 | 0.91 | KMT2A (0.50) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4584119 | 0.90 | MAPK14 (0.44) | KMT2ALMNASMN1; SMN2 | |
| SCHEMBL4910337 | 0.86 | ALDH1A1 (0.45) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4728090 | 0.86 | KMT2A (0.40) | KMT2AMEN1ALDH1A1MAPK1MAPT | |
| SCHEMBL4582536 | 0.86 | KMT2A (0.48) | KMT2AMEN1LMNAALDH1A1MAPK1 | |
| SCHEMBL4582433 | 0.85 | MAPK14 (0.41) | KMT2ALMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4582547 | 0.85 | MAPT (0.44) | KMT2ALMNAALDH1A1MAPK1MAPT | |
| SCHEMBL4583020 | 0.85 | MAPK14 (0.40) | KMT2AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008028690-A1 | 1-(HET)ARYL-3-[HETARYL-PIPERIDIN-4-YL]-THIOUREAS AS MODULATORS OF THE EP2 RECEPTOR | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | claimed |
| EP-1903037-A1 | 1-(hetero)aryl-3-[heteroaryl-piperidin-4yl]-thiourea derivatives as modulators of EP2 receptors | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-03-26 | — | — | EP | disclosed |