Salicylic Acid

Salicylic Acid

SCHEMBL458273

O=C([O-])c1ccccc1O.O=C([O-])c1ccccc1O.[K+].[K+]

nearest known ligand 0.91

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHE

The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.91
HPGD P15428 5/20 0.91
ALDH1A1 P00352 3/20 0.91
SMN1; SMN2 Q16637 2/20 0.58
CA1 P00915 2/20 0.58
CA9 Q16790 2/20 0.58
CA12 O43570 1/20 0.58
CA2 P00918 1/20 0.58
HMGB1 P09429 1/20 0.58
CA4 P22748 1/20 0.58
CA6 P23280 1/20 0.58
CA7 P43166 1/20 0.58
NAPRT Q6XQN6 1/20 0.58
CA14 Q9ULX7 1/20 0.58
HSD17B10 Q99714 3/20 0.56
TSHR P16473 2/20 0.56
MAPT P10636 2/20 0.56
GAA P10253 2/20 0.52
MPO P05164 1/20 0.52
HIF1A Q16665 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Salicylic Acid SCHEMBL106935 1.00 KDM4E (0.91) KDM4EHPGDALDH1A1SMN1; SMN2CA1
Salicylic Acid SCHEMBL6844323 0.98 KDM4E (0.86) KDM4EHPGDALDH1A1SMN1; SMN2CA1
Salicylic Acid SCHEMBL30718047 0.98 KDM4E (0.95) KDM4EHPGDALDH1A1SMN1; SMN2CA1
Salicylic Acid SCHEMBL28814249 0.98 KDM4E (0.86) KDM4EHPGDALDH1A1SMN1; SMN2CA1
Salicylic Acid SCHEMBL8683263 0.98 KDM4E (0.95) KDM4EHPGDALDH1A1SMN1; SMN2CA1
Salicylic Acid SCHEMBL6249450 0.97 KDM4E (0.95) KDM4EHPGDALDH1A1SMN1; SMN2CA1
Salicylic Acid SCHEMBL28076184 0.95 KDM4E (0.91) KDM4EHPGDALDH1A1SMN1; SMN2CA1
Salicylic Acid SCHEMBL299753 0.95 KDM4E (0.91) KDM4EHPGDALDH1A1SMN1; SMN2CA1
Salicylic Acid SCHEMBL12477386 0.95 KDM4E (0.91) KDM4EHPGDALDH1A1SMN1; SMN2CA1
Salicylic Acid SCHEMBL9183232 0.95 KDM4E (0.91) KDM4EHPGDALDH1A1SMN1; SMN2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012032364-A1 STABILIZED SOLUTION OF ORTHO-SILICIC ACID BASED ON SALICYLIC ACID AS EFFECTIVE INHIBITOR OF ITS POLYMERIZATION, ITS PREPARATION AND USE CREOGEN D.O.O. (HR) 2012-03-15 WO disclosed
EP-1212275-B1 A PROCESS FOR PRODUCING DIACIDS BY CARBOXYLATION OF PHENOLIC COMPOUNDS MOSSI & GHISOLFI INT SA (LU) 2005-02-23 EP disclosed
EP-1212275-A1 A PROCESS FOR PRODUCING DIACIDS BY CARBOXYLATION OF PHENOLIC COMPOUNDS Mossi & Ghisolfi Overseas S.A. (LU) 2002-06-12 EP disclosed
US-6316665-B1 REACTING POLYHYDROXYAROMATIC COMPOUND WITH BASIC SALT IN CARBON DIOXIDE PRESENCE; DISPROPORTIONATION, ISOMERIZATION, HEATING; OXIDATION-FREE REACTION; BY-PRODUCT INHIBITION SHELL OIL COMPANY 2001-11-13 US disclosed
US-6309471-B1 Rapid removal of iodine stains ECOLAB, INC. 2001-10-30 US disclosed
WO-2001016073-A1 A PROCESS FOR PRODUCING DIACIDS BY CARBOXYLATION OF PHENOLIC COMPOUNDS MOSSI & GHISOLFI OVERSEAS S.A. (IT) 2001-03-08 WO disclosed