Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.61 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | BCR | P11274 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378411 | 0.84 | JAK2 (0.82) | JAK2PLK1AURKAAURKBPIK3CG | |
| SCHEMBL13588591 | 0.80 | JAK2 (0.72) | JAK2PLK1AURKAAURKBPIK3CG | |
| SCHEMBL4375081 | 0.76 | JAK2 (1.00) | JAK2PLK1AURKAAURKBJAK3 | |
| SCHEMBL4375286 | 0.74 | JAK2 (0.82) | JAK2PLK1AURKAAURKBJAK3 | |
| SCHEMBL4583039 | 0.73 | JAK2 (0.49) | JAK2PLK1AURKAAURKBSYK | |
| SCHEMBL7468958 | 0.73 | ABL1 (0.76) | JAK2PLK1ABL1BCRPDGFRB | |
| SCHEMBL4378544 | 0.73 | JAK2 (0.67) | JAK2PIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL4733852 | 0.73 | PLK1 (0.84) | JAK2PLK1SYKPIK3CGPIK3CA | |
| SCHEMBL4375324 | 0.72 | JAK2 (0.89) | JAK2PLK1AURKAAURKBJAK3 | |
| SCHEMBL4735155 | 0.72 | PLK1 (1.00) | JAK2PLK1SYKPIK3CAJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |