Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378411 | 0.75 | JAK2 (0.82) | JAK2AURKAAURKBPLK1PIK3CA | |
| SCHEMBL4583044 | 0.73 | JAK2 (0.61) | JAK2AURKAAURKBPLK1PIK3CA | |
| SCHEMBL13588591 | 0.72 | JAK2 (0.72) | JAK2AURKAAURKBPLK1PIK3CA | |
| SCHEMBL4375081 | 0.67 | JAK2 (1.00) | JAK2AURKAAURKBPLK1HDAC1 | |
| SCHEMBL4375286 | 0.66 | JAK2 (0.82) | JAK2AURKAAURKBPLK1HDAC1 | |
| SCHEMBL4379888 | 0.66 | JAK2 (1.00) | JAK2AURKAAURKBPLK1HDAC1 | |
| SCHEMBL7470116 | 0.66 | JAK2 (0.68) | JAK2AURKAAURKBPLK1HDAC1 | |
| SCHEMBL7475764 | 0.66 | JAK2 (0.71) | JAK2PLK1HDAC1HDAC6JAK3 | |
| SCHEMBL4378544 | 0.65 | JAK2 (0.67) | JAK2PIK3CAPIK3CBPIK3CGABL1 | |
| SCHEMBL3598695 | 0.65 | JAK2 (0.56) | JAK2AURKAAURKBPLK1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |