Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.72 |
| ▸ | DHPS | P49366 | 1/20 | 0.53 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.51 |
| ▸ | AKT2 | P31751 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | NEK4 | P51957 | 3/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.47 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.47 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | PRKCG | P05129 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583102 | 0.87 | AKT1 (0.72) | AKT1DHPSAKT3AKT2ROCK1 | |
| SCHEMBL4584069 | 0.85 | AKT1 (0.53) | AKT1AKT3AKT2ROCK1GSK3B | |
| SCHEMBL4584895 | 0.84 | AKT1 (1.00) | AKT1AKT3AKT2ROCK1RPS6KA5 | |
| SCHEMBL4583609 | 0.83 | AKT1 (1.00) | AKT1AKT3AKT2ROCK1RPS6KA5 | |
| SCHEMBL8240376 | 0.82 | AKT1 (0.65) | AKT1AKT3AKT2ROCK1RPS6KA5 | |
| SCHEMBL22044904 | 0.80 | DYRK1A (0.51) | AKT1ROCK1GSK3BNEK4PRKCD | |
| SCHEMBL4583466 | 0.79 | AKT1 (0.77) | AKT1AKT3AKT2 | |
| SCHEMBL4584324 | 0.76 | AKT1 (0.85) | AKT1AKT3AKT2ROCK1RPS6KA5 | |
| SCHEMBL16716193 | 0.76 | DHPS (0.53) | AKT1DHPSAKT3AKT2ROCK1 | |
| SCHEMBL4583056 | 0.76 | AKT1 (0.84) | AKT1AKT3AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |