Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPEP | Q07075 | 13/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680752 | 1.00 | ENPEP (0.37) | ENPEPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL27882009 | 0.98 | ENPEP (0.36) | ENPEPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL2680846 | 0.86 | APP (0.41) | ENPEPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL6589960 | 0.86 | APP (0.41) | ENPEPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL8813035 | 0.84 | TP53 (0.41) | ENPEPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL5637992 | 0.83 | TSHR (0.44) | ENPEPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL8810688 | 0.82 | TP53 (0.39) | ENPEPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL11341696 | 0.80 | PTGS1 (0.36) | ENPEPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL11872496 | 0.80 | TSHR (0.46) | ENPEPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL8811502 | 0.79 | TP53 (0.45) | ENPEPTP53S1PR2S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1905765-A1 | 6-arylamino-5-cyano-4-pyrimidinone as PDE9A-inhibitors | Boehringer Ingelheim International GmbH (DE) | 2008-04-02 | — | — | EP | disclosed |
| EP-1644339-B1 | 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2008-01-23 | — | — | EP | disclosed |