Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 10/20 | 0.73 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | PGR | P06401 | 1/20 | 0.73 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.73 |
| ▸ | PDE4A | P27815 | 1/20 | 0.73 |
| ▸ | BLVRB | P30043 | 1/20 | 0.73 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.73 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.73 |
| ▸ | PPID | Q08752 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459545 | 0.89 | XDH (0.59) | XDHABCC4ABCB11PGRCHRM1 | |
| SCHEMBL19523341 | 0.87 | XDH (0.79) | XDHABCC4ABCB11PGRCHRM1 | |
| SCHEMBL30253977 | 0.85 | XDH (0.76) | XDHABCC4ABCB11PGRCHRM1 | |
| SCHEMBL27895928 | 0.85 | XDH (0.76) | XDHABCC4ABCB11PGRCHRM1 | |
| SCHEMBL8866996 | 0.85 | XDH (0.72) | XDHABCC4ABCB11PGRCHRM1 | |
| SCHEMBL23417559 | 0.84 | XDH (0.85) | XDHABCC4ABCB11PGRCHRM1 | |
| SCHEMBL29460288 | 0.84 | XDH (0.74) | XDHABCC4ABCB11PGRCHRM1 | |
| SCHEMBL8867597 | 0.84 | XDH (0.74) | XDHABCC4ABCB11PGRCHRM1 | |
| SCHEMBL30804874 | 0.84 | XDH (0.74) | XDHABCC4ABCB11PGRCHRM1 | |
| Febuxostat SCHEMBL29398803 | 0.84 | XDH (1.00) | XDHABCC4ABCB11PGRCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165662-A1 | PREPARATION OF FEBUXOSTAT | DR. REDDY'S LABORATORIES, INC. (US) | 2013-06-27 | — | — | US | claimed |
| EP-2563768-A2 | PREPARATION OF FEBUXOSTAT | Dr. Reddy's Laboratories Ltd. (IN) | 2013-03-06 | — | — | EP | claimed |
| WO-2011139886-A2 | PREPARATION OF FEBUXOSTAT | DR. REDDY'S LABORATORIES LTD. (IN) | 2011-11-10 | — | — | WO | claimed |
| US-20150141658-A1 | PREPARATION OF FEBUXOSTAT | REDDYS LAB LTD DR (IN) | 2015-05-21 | — | — | US | disclosed |
| US-20150141658-A1 | PREPARATION OF FEBUXOSTAT | REDDYS LAB LTD DR (IN) | 2015-05-21 | — | — | US | disclosed |
| US-20150141658-A1 | PREPARATION OF FEBUXOSTAT | REDDYS LAB LTD DR (IN) | 2015-05-21 | — | — | US | disclosed |
| US-8969582-B2 | Preparation of febuxostat | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-03-03 | — | — | US | disclosed |
| US-8969582-B2 | Preparation of febuxostat | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-03-03 | — | — | US | disclosed |
| US-8969582-B2 | Preparation of febuxostat | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-03-03 | — | — | US | disclosed |
| US-20130165662-A1 | PREPARATION OF FEBUXOSTAT | DR. REDDY'S LABORATORIES, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165662-A1 | PREPARATION OF FEBUXOSTAT | DR. REDDY'S LABORATORIES, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165662-A1 | PREPARATION OF FEBUXOSTAT | DR. REDDY'S LABORATORIES, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| EP-2563768-A2 | PREPARATION OF FEBUXOSTAT | Dr. Reddy's Laboratories Ltd. (IN) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011139886-A2 | PREPARATION OF FEBUXOSTAT | DR. REDDY'S LABORATORIES LTD. (IN) | 2011-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141658-A1 | PREPARATION OF FEBUXOSTAT | FIP1L1, FECH, FBP1 | XDH 36/4885ABCC4 4462/4885ABCB11 3777/4885 |
| US-20130165662-A1 | PREPARATION OF FEBUXOSTAT | FIP1L1, FECH, FBP1 | XDH 36/4885ABCC4 4462/4885ABCB11 3777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.