Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829959 | 0.76 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL23995705 | 0.69 | CRHBP (0.34) | CRHBPCRHR2ALDH1A1 | |
| SCHEMBL27172964 | 0.68 | ALDH1A1 (0.37) | ALDH1A1TDP1 | |
| SCHEMBL2244583 | 0.68 | CRHBP (0.53) | CRHBPCRHR2 | |
| SCHEMBL3651855 | 0.67 | ALDH1A1 (0.43) | ALDH1A1 | |
| SCHEMBL35211321 | 0.67 | CRHBP (0.33) | CRHBPCRHR2 | |
| SCHEMBL35211323 | 0.67 | CRHBP (0.33) | CRHBPCRHR2 | |
| SCHEMBL1994684 | 0.67 | CRHBP (0.63) | CRHBPCRHR2ALDH1A1 | |
| Nitric Acid SCHEMBL8647053 | 0.67 | CRHBP (0.57) | CRHBPCRHR2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3737938 | 0.67 | CRHBP (0.52) | CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |