Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | LMNA | P02545 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1192289 | 0.83 | ALDH1A1 (1.00) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1193137 | 0.82 | MAPT (1.00) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL5950015 | 0.82 | MAPT (0.71) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL459965 | 0.81 | MAPT (0.62) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1192644 | 0.80 | MAPT (1.00) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL459968 | 0.80 | MAPT (0.76) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL27931604 | 0.79 | MAPT (0.71) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL3986308 | 0.78 | MAPT (0.72) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL9899836 | 0.77 | MAPT (0.67) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL12457340 | 0.77 | MAPT (0.67) | MAPTALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614052-A1 | NOVEL PIPERAZINE ANALOGS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS | Bristol-Myers Squibb Company (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033736-A1 | NOVEL PIPERAZINE ANALOGS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-15 | — | — | WO | disclosed |