Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | CDK4 | P11802 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380141 | 0.86 | JAK2 (0.70) | JAK2MAPTUSP2TSHRCASP1 | |
| SCHEMBL4381182 | 0.83 | JAK2 (0.60) | JAK2JAK3AURKACDK4CDK2 | |
| SCHEMBL4584094 | 0.83 | JAK2 (0.59) | JAK2JAK3CDK2CDK9HDAC1 | |
| SCHEMBL4602091 | 0.82 | GSK3B (0.57) | JAK2JAK3HDAC1HDAC6 | |
| SCHEMBL4583408 | 0.79 | JAK2 (0.57) | JAK2JAK3HDAC1HDAC6 | |
| SCHEMBL4603072 | 0.79 | JAK2 (0.54) | JAK2JAK3AURKACDK2CDK7 | |
| SCHEMBL27739754 | 0.79 | JAK2 (0.66) | JAK2JAK3HDAC1HDAC6 | |
| SCHEMBL4377340 | 0.79 | JAK2 (0.72) | JAK2JAK3CDK2CDK7CDK9 | |
| SCHEMBL14021615 | 0.78 | JAK2 (0.57) | JAK2MAPTJAK3HTTCDK2 | |
| SCHEMBL4382992 | 0.78 | JAK2 (0.70) | JAK2JAK3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |