Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TNF | P01375 | 7/20 | 0.44 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384637 | 0.82 | POLB (0.39) | POLBALDH1A1TP53 | |
| SCHEMBL4376740 | 0.82 | POLB (0.51) | POLBTNFALDH1A1GAATP53 | |
| SCHEMBL20974084 | 0.78 | POLB (0.48) | POLBALDH1A1SMN1; SMN2GAATP53 | |
| SCHEMBL17916051 | 0.78 | POLB (0.51) | POLBTNFPDE4APDE4BPDE4C | |
| SCHEMBL20974361 | 0.75 | POLB (0.45) | POLBALDH1A1GAATP53 | |
| SCHEMBL22805334 | 0.72 | ALDH1A1 (0.53) | POLBTNFMAPTALDH1A1GAA | |
| SCHEMBL4378072 | 0.70 | POLB (0.43) | POLBALDH1A1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL16165000 | 0.70 | POLB (0.55) | POLBMAPTALDH1A1TP53 | |
| SCHEMBL16165001 | 0.70 | POLB (0.55) | POLBMAPTALDH1A1TP53 | |
| SCHEMBL6694212 | 0.69 | TNF (0.69) | POLBTNFPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |