Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583474 | 0.82 | POLB (0.46) | POLBALDH1A1TP53 | |
| SCHEMBL4376740 | 0.81 | POLB (0.51) | POLBALDH1A1TP53LMNAKMT2A | |
| SCHEMBL4381017 | 0.77 | ALDH1A1 (0.46) | ALDH1A1LMNA | |
| SCHEMBL20974084 | 0.77 | POLB (0.48) | POLBALDH1A1KDM4ETP53LMNA | |
| SCHEMBL4371317 | 0.76 | ALDH1A1 (0.48) | ALDH1A1LMNA | |
| SCHEMBL20974361 | 0.74 | POLB (0.45) | POLBALDH1A1KDM4ETP53LMNA | |
| SCHEMBL1527214 | 0.71 | KMT2A (0.46) | POLBALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL6923510 | 0.70 | POLB (0.49) | POLBALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL6923507 | 0.70 | POLB (0.49) | POLBALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL4378072 | 0.69 | POLB (0.43) | POLBALDH1A1KDM4ETP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| EP-2114388-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008098105-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |