Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 5/20 | 0.60 |
| ▸ | IKBKB | O14920 | 3/20 | 0.58 |
| ▸ | CHUK | O15111 | 3/20 | 0.58 |
| ▸ | PRKCI | P41743 | 2/20 | 0.54 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1230522 | 0.79 | IKBKB (0.46) | NUDT1IKBKBCHUKPRKCIIGF1R | |
| SCHEMBL30649183 | 0.76 | AKT1 (0.61) | NUDT1IKBKBCHUKPRKCIIGF1R | |
| SCHEMBL10125059 | 0.76 | AKT1 (0.61) | NUDT1IKBKBCHUKPRKCIIGF1R | |
| SCHEMBL2240671 | 0.75 | AURKB (0.71) | NUDT1IKBKBCHUKPRKCIIGF1R | |
| SCHEMBL4772891 | 0.75 | NUDT1 (1.00) | NUDT1IKBKBCHUKPRKCIIGF1R | |
| SCHEMBL4791333 | 0.73 | IKBKB (1.00) | NUDT1IKBKBCHUKPRKCIIGF1R | |
| SCHEMBL1719613 | 0.72 | NUDT1 (0.57) | NUDT1IKBKBCHUKPRKCIIGF1R | |
| SCHEMBL2606616 | 0.71 | NUDT1 (0.66) | NUDT1IKBKBCHUKPRKCIIGF1R | |
| SCHEMBL30808539 | 0.71 | NUDT1 (0.66) | NUDT1IKBKBCHUKPRKCIIGF1R | |
| SCHEMBL953404 | 0.71 | CDC7 (0.55) | NUDT1IKBKBCHUKPRKCIIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |