Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 3/20 | 1.00 |
| ▸ | IKBKB | O14920 | 4/20 | 0.60 |
| ▸ | CHUK | O15111 | 4/20 | 0.60 |
| ▸ | PRKCI | P41743 | 2/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.55 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | PAK4 | O96013 | 2/20 | 0.55 |
| ▸ | CSF1R | P07333 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.55 |
| ▸ | PRKACA | P17612 | 2/20 | 0.55 |
| ▸ | FLT1 | P17948 | 2/20 | 0.55 |
| ▸ | LTK | P29376 | 2/20 | 0.55 |
| ▸ | GRK5 | P34947 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10125148 | 0.87 | NUDT1 (0.77) | NUDT1IKBKBCHUKPRKCICSNK1A1 | |
| SCHEMBL10125427 | 0.86 | NUDT1 (0.75) | NUDT1IKBKBCHUKPRKCICSNK1A1 | |
| SCHEMBL4764911 | 0.83 | NUDT1 (0.71) | NUDT1IKBKBCHUKPRKCICSNK1A1 | |
| SCHEMBL10125400 | 0.83 | NUDT1 (0.71) | NUDT1IKBKBCHUKPRKCICSNK1A1 | |
| SCHEMBL12348092 | 0.80 | NUDT1 (0.67) | NUDT1IKBKBCHUKPRKCICSNK1A1 | |
| SCHEMBL30563455 | 0.80 | NUDT1 (0.67) | NUDT1CSNK1A1TYRO3DYRK1BCDK9 | |
| SCHEMBL29665034 | 0.80 | JAK2 (0.78) | NUDT1IKBKBCHUKPRKCICSNK1A1 | |
| SCHEMBL2606616 | 0.80 | NUDT1 (0.66) | NUDT1IKBKBCHUKPRKCICSNK1A1 | |
| SCHEMBL30808539 | 0.80 | NUDT1 (0.66) | NUDT1IKBKBCHUKPRKCICSNK1A1 | |
| SCHEMBL4764920 | 0.79 | PRKCI (0.86) | NUDT1IKBKBCHUKPRKCICSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934181-A2 | KINASE INHIBITORS | Devgen NV (BE) | 2008-06-25 | — | — | EP | claimed |
| WO-2007042321-A2 | KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-04-19 | — | — | WO | claimed |
| US-8921376-B2 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921376-B2 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-12-30 | — | — | US | disclosed |
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2007-06-14 | — | — | US | disclosed |
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | JAK2, JAK1, JAK3 | NUDT1 2466/4885IKBKB 779/4885CHUK 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.