Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 1/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28823015 | 0.83 | USP8 (0.58) | USP8ADORA1ADORA2AERBB2HSD17B10 | |
| SCHEMBL4585033 | 0.79 | ATR (0.46) | XDHADORA2AATRALDH1A1KDM4E | |
| SCHEMBL28822945 | 0.77 | KDM4E (0.53) | USP8ADORA1ADORA2AERBB2HSD17B10 | |
| SCHEMBL28823036 | 0.77 | ADORA1 (0.61) | USP8ADORA1ADORA2AERBB2HSD17B10 | |
| SCHEMBL28822974 | 0.77 | ADORA1 (0.61) | USP8ADORA1ADORA2AERBB2HSD17B10 | |
| SCHEMBL28822972 | 0.77 | KDM4E (0.53) | USP8ADORA1ADORA2AERBB2HSD17B10 | |
| SCHEMBL4583299 | 0.77 | ATR (0.47) | XDHADORA2AATRALDH1A1KDM4E | |
| SCHEMBL4585480 | 0.74 | USP8 (0.48) | USP8XDHADORA1ADORA2AHSD17B10 | |
| SCHEMBL28823040 | 0.74 | DPP4 (0.51) | USP8ADORA1ADORA2AHSD17B10ALDH1A1 | |
| SCHEMBL28822970 | 0.74 | ADORA1 (0.64) | USP8ADORA1ADORA2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407961-B2 | Pyrazine derivatives and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2008-08-05 | — | — | US | disclosed |
| CN-1871231-A | Pyrazine derivatives and pharmaceutical use thereof | ASTELLAS PHARMA INC (JP) | 2006-11-29 | — | — | CN | disclosed |
| US-20050113387-A1 | Pyrazine derivatives and pharmaceutical use thereof | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113387-A1 | Pyrazine derivatives and pharmaceutical use thereof | ADORA2A, P2RX5, ADORA1 | USP8 4884/4885XDH 474/4885KDM5A 2132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.