SCHEMBL4584577

SCHEMBL4584577

Nc1ccc(-c2c(-c3ccc(N)cc3)c(=O)c2=O)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.56
ALDH1A1 P00352 4/20 0.56
TDP1 Q9NUW8 3/20 0.56
TP53 P04637 2/20 0.56
MAPT P10636 3/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
HSD17B10 Q99714 3/20 0.46
LMNA P02545 2/20 0.46
TAAR1 Q96RJ0 2/20 0.46
HTT P42858 1/20 0.46
CA14 Q9ULX7 3/20 0.42
CA12 O43570 2/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA9 Q16790 2/20 0.42
APP P05067 1/20 0.42
BRD4 O60885 1/20 0.40
ACHE P22303 2/20 0.39
NPC1 O15118 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1109016 0.83 CYP3A4 (0.43) CYP3A4ALDH1A1TDP1TP53MAPT
SCHEMBL29450595 0.81 CYP3A4 (0.71) CYP3A4ALDH1A1TDP1TP53MAPT
SCHEMBL6020612 0.75 CYP3A4 (0.62) CYP3A4ALDH1A1TDP1TP53MAPT
Benzidine SCHEMBL720393 0.73 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TP53MAPT
SCHEMBL2024128 0.73 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TP53MAPT
SCHEMBL258287 0.73 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TP53MAPT
Benzidine SCHEMBL5140469 0.73 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TP53MAPT
SCHEMBL28842081 0.73 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TP53MAPT
Benzidine SCHEMBL29021 0.73 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TP53MAPT
SCHEMBL9330651 0.73 CYP3A4 (0.59) CYP3A4ALDH1A1TDP1TP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7411014-B2 Stabilization of polyetherimide sulfones SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-08-12 US disclosed
WO-2008063730-A2 BIAXIALLY ORIENTED FILM, LAMINATES MADE THEREFROM, AND METHOD SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-05-29 WO disclosed
US-20080118730-A1 BIAXIALLY ORIENTED FILM, LAMINATES MADE THEREFROM, AND METHOD GENERAL ELECTRIC COMPANY 2008-05-22 US disclosed
US-20070190882-A1 Laminate and method GENERAL ELECTRIC 2007-08-16 US disclosed
US-20060281840-A1 Stabilization of polyetherimide sulfones SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2006-12-14 US disclosed
EP-1639044-A2 POLYIMIDE RESIN WITH REDUCED MOLD DEPOSIT GENERAL ELECTRIC COMPANY (US) 2006-03-29 EP disclosed
US-6919422-B2 Polyimide resin with reduced mold deposit GENERAL ELECTRIC COMPANY (US) 2005-07-19 US disclosed
WO-2004113446-A2 POLYIMIDE RESIN WITH REDUCED MOLD DEPOSIT GENERAL ELECTRIC COMPANY (US) 2004-12-29 WO disclosed
US-20040260055-A1 Polyimide resin with reduced mold deposit GENERAL ELECTRIC COMPANY 2004-12-23 US disclosed