Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL1833733 | 0.90 | TSHR (0.38) | HTTSMN1; SMN2PKMKMT2AMEN1 | |
| Hydroxyamine SCHEMBL31050881 | 0.86 | CES2 (0.40) | HTTSMN1; SMN2PKMKMT2AMEN1 | |
| SCHEMBL203915 | 0.86 | CES2 (0.43) | HTTSMN1; SMN2PKMKMT2AMEN1 | |
| SCHEMBL28778351 | 0.85 | RECQL (0.47) | HTTSMN1; SMN2PKMKMT2AMEN1 | |
| SCHEMBL336420 | 0.83 | CES2 (0.42) | HTTSMN1; SMN2PKMKMT2AMEN1 | |
| Ammonia Solution, Strong SCHEMBL20291864 | 0.83 | CES2 (0.42) | HTTSMN1; SMN2PKMKMT2AMEN1 | |
| SCHEMBL16756190 | 0.83 | CES2 (0.42) | HTTSMN1; SMN2PKMKMT2AMEN1 | |
| SCHEMBL2150002 | 0.83 | CES2 (0.42) | HTTSMN1; SMN2PKMKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL11033629 | 0.83 | CES2 (0.42) | HTTSMN1; SMN2PKMKMT2AMEN1 | |
| SCHEMBL28389339 | 0.83 | CES2 (0.42) | HTTSMN1; SMN2PKMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530269-B2 | Manufacture of a polymer device | CAMBRIDGE ENTERPRISE LTD (GB) | 2013-09-10 | — | — | US | disclosed |
| EP-1631995-B1 | MANUFACTURE OF A POLYMER DEVICE | CAMBRIDGE ENTPR LTD (GB) | 2008-07-16 | — | — | EP | disclosed |
| US-20070172978-A1 | Manufacture of a polymer device | CAMBRIDGE UNIVERSITY TECHNICAL SERVICE LIMITED (GB) | 2007-07-26 | — | — | US | disclosed |