Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL10878306 | 0.94 | TDP1 (0.59) | TDP1SMN1; SMN2TSHRALDH1A1LMNA | |
| Propylene Glycol SCHEMBL10878302 | 0.94 | TDP1 (0.59) | TDP1SMN1; SMN2TSHRALDH1A1LMNA | |
| Propylene Glycol SCHEMBL16228088 | 0.92 | TDP1 (0.56) | TDP1SMN1; SMN2TSHRALDH1A1BTN3A1 | |
| Propylene Glycol SCHEMBL27656853 | 0.86 | TDP1 (0.56) | TDP1SMN1; SMN2TSHRALDH1A1GGPS1 | |
| Propylene Glycol SCHEMBL27676897 | 0.86 | TDP1 (0.56) | TDP1SMN1; SMN2TSHRALDH1A1GGPS1 | |
| Triphosphate SCHEMBL28091289 | 0.83 | TDP1 (0.46) | TDP1SMN1; SMN2BTN3A1 | |
| Propylene Glycol SCHEMBL315221 | 0.81 | TDP1 (0.67) | TDP1TSHRALDH1A1CA2LMNA | |
| Propylene Glycol SCHEMBL22285873 | 0.81 | TDP1 (0.67) | TDP1TSHRALDH1A1CA2LMNA | |
| Propylene Glycol SCHEMBL6852797 | 0.81 | TDP1 (0.67) | TDP1TSHRALDH1A1CA2LMNA | |
| Phosphoric Acid SCHEMBL28353739 | 0.81 | LMNA (0.46) | TDP1ALDH1A1CA2LMNAGGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575577-A4 | COMPOSITION FOR THE PREVENTION AND TREATMENT OF INFLAMMATION OF THE EAR | SINOFRESH HEALTHCARE INC (US) | 2008-03-19 | — | — | EP | disclosed |
| EP-1575577-A2 | COMPOSITION FOR THE PREVENTION AND TREATMENT OF INFLAMMATION OF THE EAR | SinoFresh HealthCare, Inc. (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004047729-A2 | COMPOSITION FOR THE PREVENTION AND TREATMENT OF INFLAMMATION OF THE EAR | SINOFRESH HEALTHCARE, INC. (US) | 2004-06-10 | — | — | WO | disclosed |