Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5538439 | 0.92 | GRIN2B (0.45) | GRIN2BGRIN1L3MBTL1TP53KDM4E | |
| SCHEMBL5543265 | 0.90 | GRIN2B (0.43) | GRIN2BGRIN1L3MBTL1TP53KDM4E | |
| SCHEMBL4585046 | 0.90 | L3MBTL1 (0.39) | L3MBTL1KDM4ELMNAMAPTMEN1 | |
| SCHEMBL5545763 | 0.89 | L3MBTL1 (0.42) | GRIN2BGRIN1L3MBTL1TP53KDM4E | |
| SCHEMBL14072845 | 0.89 | L3MBTL1 (0.39) | GRIN2BL3MBTL1KDM4ELMNAMEN1 | |
| SCHEMBL5547133 | 0.88 | L3MBTL1 (0.41) | GRIN2BGRIN1L3MBTL1TP53KDM4E | |
| SCHEMBL5547220 | 0.88 | GRIN2B (0.44) | GRIN2BGRIN1L3MBTL1TP53KDM4E | |
| SCHEMBL5540799 | 0.87 | MAPT (0.43) | GRIN2BGRIN1L3MBTL1TP53KDM4E | |
| SCHEMBL5545653 | 0.86 | GRIN2B (0.40) | GRIN2BGRIN1L3MBTL1TP53KDM4E | |
| SCHEMBL4998957 | 0.86 | L3MBTL1 (0.38) | L3MBTL1TP53KDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194523-A1 | Hiv Integrase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-08-14 | — | — | US | claimed |
| US-20080194523-A1 | Hiv Integrase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-08-14 | — | — | US | disclosed |
| US-20080194523-A1 | Hiv Integrase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-08-14 | — | — | US | disclosed |
| US-20080194523-A1 | Hiv Integrase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-08-14 | — | — | US | disclosed |
| WO-2007019100-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194523-A1 | Hiv Integrase Inhibitors | ING2, API5, SAMHD1 | GRIN2B 4107/4885GRIN1 3259/4885L3MBTL1 1372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.