Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 13/20 | 0.48 |
| ▸ | TDO2 | P48775 | 13/20 | 0.48 |
| ▸ | IDO2 | Q6ZQW0 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12289910 | 0.88 | IDO1 (0.49) | IDO1TDO2IDO2HTTMEN1 | |
| SCHEMBL6807692 | 0.87 | IDO1 (0.60) | IDO1TDO2IDO2HTTMEN1 | |
| SCHEMBL11904132 | 0.85 | TDO2 (0.49) | IDO1TDO2IDO2MEN1KMT2A | |
| SCHEMBL9105433 | 0.78 | TDO2 (0.61) | IDO1TDO2IDO2MEN1KMT2A | |
| SCHEMBL9107620 | 0.78 | IDO1 (0.48) | IDO1TDO2IDO2MAPTLMNA | |
| SCHEMBL9102861 | 0.74 | TDO2 (0.49) | IDO1TDO2IDO2MEN1KMT2A | |
| SCHEMBL4593874 | 0.68 | TDO2 (0.67) | IDO1TDO2IDO2HTTMAPT | |
| SCHEMBL17832376 | 0.68 | TDO2 (0.75) | IDO1TDO2IDO2MEN1KMT2A | |
| SCHEMBL12289879 | 0.67 | TDO2 (0.54) | IDO1TDO2IDO2MAPTMEN1 | |
| SCHEMBL17830818 | 0.66 | IDO1 (0.83) | IDO1TDO2IDO2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594524-A4 | USE OF TRYPTANTHRIN COMPOUNDS FOR IMMUNE POTENTIATION | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2008-09-03 | — | — | EP | claimed |
| EP-1594524-A2 | USE OF TRYPTANTHRIN COMPOUNDS FOR IMMUNE POTENTIATION | CHIRON CORPORATION (US) | 2005-11-16 | — | — | EP | claimed |
| WO-2004064759-A2 | USE OF TRYPTANTHRIN COMPOUNDS FOR IMMUNE POTENTIATION | CHIRON CORPORATION (US) | 2004-08-05 | — | — | WO | claimed |