Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 16/20 | 0.54 |
| ▸ | IDO1 | P14902 | 14/20 | 0.54 |
| ▸ | IDO2 | Q6ZQW0 | 10/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | APAF1 | O14727 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9100562 | 0.86 | TDO2 (0.64) | TDO2IDO1IDO2MAPTATM | |
| SCHEMBL9106540 | 0.85 | IDO1 (0.42) | TDO2IDO1IDO2MAPTATM | |
| SCHEMBL4593874 | 0.82 | TDO2 (0.67) | TDO2IDO1IDO2MAPTAPAF1 | |
| SCHEMBL4593450 | 0.78 | IDO1 (0.65) | TDO2IDO1IDO2ALOX15 | |
| SCHEMBL17830818 | 0.77 | IDO1 (0.83) | TDO2IDO1IDO2APAF1MEN1 | |
| SCHEMBL4587567 | 0.77 | APAF1 (0.71) | TDO2IDO1IDO2MAPTAPAF1 | |
| SCHEMBL9105381 | 0.76 | TDO2 (0.58) | TDO2IDO1IDO2MAPTALOX15 | |
| SCHEMBL9099548 | 0.73 | TDO2 (0.74) | TDO2IDO1IDO2MAPTAPAF1 | |
| SCHEMBL9220971 | 0.71 | TDO2 (0.66) | TDO2IDO1IDO2APAF1MEN1 | |
| SCHEMBL9114978 | 0.71 | TDO2 (0.70) | TDO2IDO1IDO2MAPTAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012987-B2 | Indolo[2,1-b] quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2011-09-06 | — | — | US | disclosed |
| US-8012987-B2 | Indolo[2,1-b] quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2011-09-06 | — | — | US | disclosed |