⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5411353 | 0.80 | CYP2A6 (0.41) | — | |
| SCHEMBL15637309 | 0.78 | PDK2 (0.32) | — | |
| SCHEMBL9296469 | 0.77 | NOTUM (0.37) | — | |
| SCHEMBL15638003 | 0.74 | KMO (0.37) | — | |
| SCHEMBL5584043 | 0.72 | LMNA (0.31) | — | |
| SCHEMBL59224 | 0.72 | — | — | |
| SCHEMBL39183 | 0.72 | — | — | |
| SCHEMBL9438776 | 0.71 | AHR (0.38) | — | |
| Benzene SCHEMBL8015750 | 0.70 | TSHR (0.40) | — | |
| SCHEMBL16586070 | 0.70 | CYP1A2 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 416 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115557865-B | Thioether-promoted cysteine-based bioconjugate method | 南京工业大学 | 2024-05-14 | — | — | CN | claimed |
| CN-115557865-A | Thioether-promoted cysteine-based bioconjugation method | 南京工业大学 | 2023-01-03 | — | — | CN | claimed |
| CN-110818598-A | Cathepsin inhibitor and preparation method and application thereof | 沈阳药科大学 | 2020-02-21 | — | — | CN | claimed |
| US-9242945-B2 | Substituted 2-benzylidene-2H-benzo[b][1,4]thiazin-3(4H)-ones, derivatives thereof, and therapeutic uses thereof | Temple University—Of the Commonwealth System of Higher Education (US) | 2016-01-26 | — | — | US | claimed |
| US-20140086941-A1 | SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2014-03-27 | — | — | US | claimed |
| WO-2012166586-A1 | SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-12-06 | — | — | WO | claimed |
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | claimed |
| US-7691866-B2 | 2,6-disubstituted quinazolines, quinoxalines, quinolines and isoquinolines and methods of their use as inhibitors of Raf kinase | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-04-06 | — | — | US | claimed |
| US-7671049-B2 | Pyrrole based inhibitors of glycogen synthase kinase 3 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-03-02 | — | — | US | claimed |
| EP-1653960-A4 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST | AMGEN INC (US) | 2008-11-26 | — | — | EP | claimed |
| EP-0207690-A1 | N-Substituted glutamic acid derivative and process for production and use thereof | SUNTORY LIMITED (JP) | 1987-01-07 | — | — | EP | claimed |
| US-4512989-A | IMIDOESTERS OR IMIDOTHIOESTERS | HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) | 1985-04-23 | — | — | US | claimed |
| US-4391804-A | Imidazole derivatives and fungicidal composition containing the same | HOKKO CHEMICAL INDUSTRY COMPANY, LTD. (JP) | 1983-07-05 | — | — | US | claimed |
| US-4299727-A | Disposable reversible thermometer | AKZONA INCORPORATED (US) | 1981-11-10 | — | — | US | claimed |
| EP-0007991-A1 | Substituted 2-phenylamino-imidazolines-(2), their acid addition salts, medicaments containing them and processes for their preparation | C.H. BOEHRINGER SOHN (DE) | 1980-02-20 | — | — | EP | claimed |
| EP-0007422-A1 | Substituted 2-phenylamino-imidazolines-(2), their acid addition salts, medicaments containing them and processes for their preparation | C.H. BOEHRINGER SOHN (DE) | 1980-02-06 | — | — | EP | claimed |
| US-4060623-A | 1,2,4-Triazole antimycotic compositions and use thereof | BAYER AKTIENGESELLSCHAFT (DT) | 1977-11-29 | — | — | US | claimed |
| US-4038404-A | 1,2,4-TRIAZOLE ANTIMYCOTIC COMPOSITIONS AND USE THEREOF | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-26 | — | — | US | claimed |
| US-4036967-A | 1,2,4-Triazole antimycotic compositions and use thereof | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-19 | — | — | US | claimed |
| US-4036966-A | 1,2,4-Triazole antimycotic compositions and use thereof | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-19 | — | — | US | claimed |