Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 10/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586811 | 0.92 | CCR5 (0.46) | CCR5HRH3MEN1HRH2HRH1 | |
| SCHEMBL4587622 | 0.91 | CCR5 (0.39) | CCR5HRH3MEN1 | |
| SCHEMBL4242209 | 0.83 | CCR5 (0.52) | CCR5HRH3 | |
| SCHEMBL4239850 | 0.75 | GPR119 (0.48) | CCR5 | |
| SCHEMBL4245191 | 0.75 | CCR5 (0.55) | CCR5HRH3 | |
| SCHEMBL4240166 | 0.74 | CCR5 (0.47) | CCR5HRH3 | |
| SCHEMBL4236541 | 0.74 | CCR5 (0.52) | CCR5HRH3 | |
| SCHEMBL4241995 | 0.72 | CCR5 (0.83) | CCR5 | |
| SCHEMBL4244805 | 0.68 | CCR5 (0.66) | CCR5 | |
| SCHEMBL4244600 | 0.68 | CCR5 (0.66) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708703-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC (CA) | 2008-04-09 | — | — | EP | disclosed |
| EP-1708703-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005059107-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2005-06-30 | — | — | WO | disclosed |