Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.36 |
| ▸ | MYLK | Q15746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30517254 | 1.00 | POLB (0.41) | POLBTDP1KDM4EALDH1A1MEN1 | |
| SCHEMBL4468000 | 0.90 | POLB (0.38) | POLBTDP1KDM4EALDH1A1MEN1 | |
| SCHEMBL26931901 | 0.88 | CCR5 (0.44) | POLBTDP1KDM4EALDH1A1MEN1 | |
| SCHEMBL4799391 | 0.84 | PYCR1 (0.43) | POLBTDP1KDM4EALDH1A1MEN1 | |
| SCHEMBL20633523 | 0.83 | FFAR4 (0.40) | POLBTDP1KDM4EALDH1A1MEN1 | |
| SCHEMBL582358 | 0.81 | PYCR1 (0.46) | MEN1MAPTKMT2APYCR1 | |
| SCHEMBL3476289 | 0.81 | PYCR1 (0.51) | POLBTDP1KDM4EALDH1A1MEN1 | |
| SCHEMBL16621409 | 0.81 | POLB (0.38) | POLBTDP1KDM4EALDH1A1MEN1 | |
| SCHEMBL29506818 | 0.81 | PYCR1 (0.46) | MEN1MAPTKMT2APYCR1 | |
| SCHEMBL2870657 | 0.81 | HPGD (0.44) | POLBTDP1KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |