Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326320 | 0.91 | MAPT (0.58) | MAPTPTPN2PTPN1PTPN5HTT | |
| SCHEMBL2329102 | 0.91 | SIRT2 (0.46) | HTTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL2330704 | 0.85 | MAPT (0.56) | MAPTPTPN2PTPN1PTPN5HTT | |
| SCHEMBL4589934 | 0.81 | PTPN2 (0.57) | MAPTPTPN2PTPN1PTPN5HTT | |
| SCHEMBL2330847 | 0.81 | SIRT2 (0.50) | HTTALDH1A1LMNAL3MBTL1GAA | |
| SCHEMBL2330377 | 0.81 | HPGD (0.52) | MAPTPTPN2PTPN1PTPN5HTT | |
| SCHEMBL2333148 | 0.81 | SIRT2 (0.47) | MAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2331010 | 0.79 | PTPN2 (0.56) | MAPTPTPN2PTPN1PTPN5HTT | |
| SCHEMBL2326870 | 0.79 | SIRT2 (0.44) | ALDH1A1LMNAGAAATM | |
| SCHEMBL2326303 | 0.79 | PTPN2 (0.56) | MAPTPTPN2PTPN1PTPN5HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345075-B2 | 6-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]hexanoic acid isopropyl ester; antiinflammatory agents; microglia activators; neurodegenerative diseases | SCHERING AKTIENGESELLSCHAFT (DE) | 2008-03-18 | — | — | US | disclosed |
| US-20060205803-A1 | 1,2 Diarylbenzimidazoles and their pharmaceutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205803-A1 | 1,2 Diarylbenzimidazoles and their pharmaceutical use | ATP6V1B2, IL1B, GMFG | MAPT 829/4885PTPN2 1930/4885PTPN1 2216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.