ATP6V1B2

V-type proton ATPase subunit B, brain isoform · P21281 · ATP6V1B2 on Sugi Atlas →

2,579 patent compounds predicted against ATP6V1B2, 2,031 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Enoxacin (SCHEMBL33963)	1.00	1/20
Enoxacin (SCHEMBL2635855)	1.00	1/20
Norfloxacin (SCHEMBL8387763)	0.84	1/20
SCHEMBL4904141	0.79	1/20
SCHEMBL8044673	0.79	1/20
SCHEMBL2855751	0.78	1/20
Enoxacin (SCHEMBL1822609)	0.77	1/20
Ciprofloxacin (SCHEMBL5029227)	0.75	1/20
Lomefloxacin (SCHEMBL5697650)	0.74	1/20
Enoxacin (SCHEMBL8922307)	0.74	1/20
Enoxacin (SCHEMBL7355005)	0.70	1/20
Esafloxacin (SCHEMBL1344407)	0.69	1/20
SCHEMBL659309	0.69	1/20
SCHEMBL311935	0.68	1/20
Esafloxacin (SCHEMBL1231132)	0.68	1/20
SCHEMBL4902751	0.66	1/20
SCHEMBL312827	0.65	1/20
SCHEMBL5083883	0.65	1/20
Norfloxacin (SCHEMBL3473)	0.65	1/20
Pipemidic Acid (SCHEMBL135557)	0.65	1/20

Clinical trials — most relevant to ATP6V1B2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Possible Efficacy and Safety of Lansoprazole Co-administration With Neoadjuvant Chemotherapy in Women With Breast Cancer	PHASE3	COMPLETED
Copper Histidine Therapy for Menkes Diseases	PHASE1/PHASE2	COMPLETED
Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure	PHASE2	UNKNOWN
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease	PHASE2	ACTIVE_NOT_RECRUITING
Efavirenz for Patients With Alzheimer's Disease	PHASE1	COMPLETED
Choline Effects - Pre-symptomatic AD	PHASE1	COMPLETED
Validation of a Prognostic Biomarker Using Brain Diffusion MRI in X-linked Adrenoleukodystrophy	nan	NOT_YET_RECRUITING
Brain Involvement in Dystrophinopathies Part 2	nan	COMPLETED
Speech and Short-term Memory Functions in Dyslexia: a Combined MEG and EEG Study	nan	UNKNOWN
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Clearance Mechanisms in Atypical Neurodegenerative Diseases	nan	UNKNOWN
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Fluorescence and Glioma Heterogeneity	nan	COMPLETED
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Evaluation of Transcranial Photobiomodulation in Autism Spectrum Disorder	nan	COMPLETED
Exchangeable and Relative Exchangeable Copper as an Alternative to 24-Hour Urinary Copper in Wilson's Disease Monitoring	nan	COMPLETED
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte	nan	COMPLETED
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN
Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients	nan	COMPLETED
Defining the Brain Phenotype of Children With Williams Syndrome	nan	RECRUITING
Transcranial Photobiomodulation Therapy for the Treatment of Autistic Traits in Children and Adolescents With ADHD	nan	COMPLETED
CADASIL Disease Discovery	nan	COMPLETED
Parkinson's Families Project	nan	RECRUITING
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients	nan	NOT_YET_RECRUITING
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING
Clinical Profile and Out Come of Children With Wilson's Disease	nan	UNKNOWN
Cerebrospinal Fluid Mitochondrial Biomarkers in Ischemic Stroke and Alzheimer Disease	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ATP6V1B2 binder may also engage these)

Protein	Name	Similarity
P31407	—	1.000	P31407 →
Q5R5V5	—	1.000	Q5R5V5 →
P31408	—	1.000	P31408 →
P62814	—	1.000	P62814 →
P31410	—	1.000	P31410 →
Q91YH6	—	1.000	Q91YH6 →
P16140	—	1.000	P16140 →
P62815	—	1.000	P62815 →
ATP6V1B1	V-type proton ATPase subunit B, kidney isoform	1.000	landscape →
Q19626	—	1.000	Q19626 →
Q9N5A0	—	1.000	Q9N5A0 →
P31409	—	1.000	P31409 →
Q43433	—	1.000	Q43433 →
P48413	—	1.000	P48413 →
P31401	—	0.999	P31401 →
P22550	—	0.999	P22550 →
Q43432	—	0.999	Q43432 →
Q48VL2	—	0.999	Q48VL2 →
Q59PT0	—	0.999	Q59PT0 →
P31411	—	0.999	P31411 →
Q1JNS7	—	0.999	Q1JNS7 →
Q26976	—	0.998	Q26976 →
A2RC98	—	0.998	A2RC98 →
Q619C0	—	0.998	Q619C0 →
P0DA07	—	0.998	P0DA07 →
Q5XE49	—	0.998	Q5XE49 →
P11574	—	0.998	P11574 →
Q1JDX0	—	0.997	Q1JDX0 →
Q40078	—	0.997	Q40078 →
Q25691	—	0.997	Q25691 →