Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM4B | O94953 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 7/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9422688 | 0.84 | DRD2 (0.63) | DRD2DRD4GRM2SIGMAR1KDM4A | |
| Hydrochloric Acid SCHEMBL9305904 | 0.83 | DRD2 (0.62) | DRD2DRD4GRM2SIGMAR1KDM4A | |
| SCHEMBL4587723 | 0.80 | DRD2 (0.57) | DRD2DRD4GRM2SIGMAR1KDM4A | |
| SCHEMBL9311321 | 0.79 | DRD2 (0.66) | DRD2DRD4GRM2SIGMAR1KDM4A | |
| SCHEMBL1401478 | 0.79 | DRD2 (0.56) | DRD2DRD4GRM2SIGMAR1KDM4A | |
| SCHEMBL1401365 | 0.79 | DRD2 (0.56) | DRD2DRD4GRM2SIGMAR1KDM4A | |
| Hydrochloric Acid SCHEMBL4589565 | 0.78 | DRD2 (0.55) | DRD2DRD4GRM2KDM4AKDM4B | |
| SCHEMBL1401419 | 0.77 | DRD2 (0.60) | DRD2DRD4GRM2SIGMAR1KDM4A | |
| SCHEMBL4587366 | 0.77 | DRD2 (0.56) | DRD2DRD4GRM2SIGMAR1KDM4A | |
| Hydrochloric Acid SCHEMBL1401480 | 0.76 | DRD2 (0.58) | DRD2DRD4GRM2SIGMAR1KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326720-B2 | Phenyl- and pyridylpiperidines with TNF activity | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | claimed |