Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.40 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3507727 | 0.84 | TDP1 (0.43) | IDO1HTTCYP3A4HIF1ALMNA | |
| SCHEMBL29439097 | 0.84 | IDO1 (0.54) | IDO1HTTCYP3A4LMNASMN1; SMN2 | |
| SCHEMBL895205 | 0.84 | IDO1 (0.54) | IDO1HTTCYP3A4LMNASMN1; SMN2 | |
| SCHEMBL29954411 | 0.83 | PSEN1 (0.39) | IDO1HTTCYP3A4HIF1ALMNA | |
| SCHEMBL588062 | 0.83 | CYP3A4 (0.48) | IDO1HTTCYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL5747336 | 0.81 | NOS3 (0.39) | IDO1HTTCYP3A4HIF1ALMNA | |
| SCHEMBL2597823 | 0.81 | HIF1A (0.61) | IDO1HTTCYP3A4HIF1ALMNA | |
| SCHEMBL7451651 | 0.81 | HDAC3 (0.39) | IDO1CYP3A4SMN1; SMN2TDP1CYP2C9 | |
| SCHEMBL2236579 | 0.81 | PYCR1 (0.42) | IDO1HTTCYP3A4HIF1ALMNA | |
| SCHEMBL2318939 | 0.81 | ERN1 (0.47) | IDO1HTTCYP3A4HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |