Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SCN4A | P35499 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4588852 | 0.80 | MAPT (0.52) | SMN1; SMN2RAB9AL3MBTL1NPC1TSHR | |
| SCHEMBL8514102 | 0.79 | MAPT (0.60) | SMN1; SMN2RAB9AL3MBTL1NPC1TSHR | |
| SCHEMBL29519243 | 0.79 | MAPT (0.68) | SMN1; SMN2RAB9AL3MBTL1NPC1TSHR | |
| SCHEMBL5015061 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AL3MBTL1NPC1TSHR | |
| SCHEMBL4590671 | 0.79 | SMN1; SMN2 (0.74) | SMN1; SMN2RAB9AL3MBTL1NPC1TSHR | |
| SCHEMBL5015059 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AL3MBTL1NPC1TSHR | |
| SCHEMBL20767920 | 0.79 | SMN1; SMN2 (0.76) | SMN1; SMN2RAB9AL3MBTL1NPC1TSHR | |
| Hydrochloric Acid SCHEMBL4060481 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AL3MBTL1NPC1TSHR | |
| SCHEMBL17221901 | 0.76 | RAB9A (0.48) | SMN1; SMN2RAB9AL3MBTL1NPC1TSHR | |
| Hydrochloric Acid SCHEMBL4056520 | 0.75 | ALDH1A1 (0.69) | SMN1; SMN2RAB9AL3MBTL1TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |