SCHEMBL4590023

SCHEMBL4590023

[CH2]C(CCc1cccc(Cl)c1)SCCC=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.43
CHRM1 P11229 1/20 0.43
CHRM3 P20309 1/20 0.43
TAAR1 Q96RJ0 4/20 0.41
KMT2A Q03164 2/20 0.40
IDO1 P14902 1/20 0.40
TDO2 P48775 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
ALDH1A1 P00352 2/20 0.37
AOC3 Q16853 1/20 0.37
HTR3E A5X5Y0 1/20 0.37
HTR3B O95264 1/20 0.37
HTR3A P46098 1/20 0.37
HTR3D Q70Z44 1/20 0.37
HTR3C Q8WXA8 1/20 0.37
C3AR1 Q16581 1/20 0.37
PNMT P11086 2/20 0.37
DAO P14920 2/20 0.36
BACE1 P56817 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4589469 0.78 TAAR1 (0.41) TAAR1IDO1ALDH1A1PNMT
SCHEMBL67484 0.77 TAAR1 (0.57) CHRM2CHRM1CHRM3TAAR1KMT2A
SCHEMBL4589241 0.74 CHRM2 (0.42) CHRM2CHRM1CHRM3TAAR1KMT2A
SCHEMBL5539189 0.74 TAAR1 (0.53) CHRM2CHRM1CHRM3TAAR1KMT2A
SCHEMBL4590021 0.73 CHRM2 (0.43) CHRM2CHRM1CHRM3TAAR1KMT2A
SCHEMBL5541023 0.72 TAAR1 (0.52) CHRM2CHRM1CHRM3TAAR1KMT2A
SCHEMBL5539437 0.71 TAAR1 (0.50) CHRM2CHRM1CHRM3TAAR1KMT2A
SCHEMBL4460308 0.70 IDO1 (0.49) CHRM2CHRM1CHRM3TAAR1KMT2A
SCHEMBL27495396 0.70 IDO1 (0.60) CHRM2CHRM1CHRM3TAAR1KMT2A
SCHEMBL4589236 0.68 CHRM2 (0.43) CHRM2CHRM1CHRM3TAAR1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1937656-A1 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS BETA 2 ADRENOCEPTOR AGONISTS AstraZeneca AB (SE) 2008-07-02 EP disclosed
WO-2007027134-A1 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS ASTRAZENECA AB (SE) 2007-03-08 WO disclosed