Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 12/20 | 0.46 |
| ▸ | CHUK | O15111 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590194 | 0.93 | IKBKB (0.46) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL4595720 | 0.92 | IKBKB (0.45) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL5034346 | 0.84 | IKBKB (0.44) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL4588693 | 0.83 | IKBKB (0.66) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL14528352 | 0.80 | IKBKB (0.52) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL5040242 | 0.80 | IKBKB (0.49) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL5035290 | 0.76 | IKBKB (0.52) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL4590178 | 0.75 | IKBKB (0.66) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL4589503 | 0.75 | IKBKB (0.65) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL4589931 | 0.71 | IKBKB (0.62) | IKBKBCHUKAURKAFLT3CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269291-A1 | Chemical Compounds | GLAXOSMITHKLINE LLC | 2008-10-30 | — | — | US | disclosed |
| US-20080269291-A1 | Chemical Compounds | GLAXOSMITHKLINE LLC | 2008-10-30 | — | — | US | disclosed |
| US-20080269291-A1 | Chemical Compounds | GLAXOSMITHKLINE LLC | 2008-10-30 | — | — | US | disclosed |
| EP-1948187-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007062318-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007062318-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269291-A1 | Chemical Compounds | IDO2, IKBKG, NFKBIA | IKBKB 8/4885CHUK 28/4885AURKA 1253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.