Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 14/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300714 | 0.82 | KDM4E (0.39) | MCL1KDM4EPOLBL3MBTL1 | |
| SCHEMBL27766757 | 0.77 | CES2 (0.37) | MCL1 | |
| SCHEMBL2305287 | 0.76 | MAPK1 (0.36) | MCL1KDM4EPOLBHSD17B10 | |
| SCHEMBL2302542 | 0.75 | SIRT1 (0.33) | SIRT1MCL1KDM4EPOLBL3MBTL1 | |
| SCHEMBL9931272 | 0.72 | MCL1 (0.53) | SIRT1SIRT2MCL1EPHX1RECQL | |
| SCHEMBL1792301 | 0.72 | MCL1 (0.53) | SIRT1SIRT2MCL1EPHX1RECQL | |
| SCHEMBL7499527 | 0.72 | SIRT1 (0.38) | SIRT1SIRT2MCL1EPHX1SIRT3 | |
| SCHEMBL3968327 | 0.72 | MCL1 (0.53) | SIRT1SIRT2MCL1EPHX1RECQL | |
| SCHEMBL17301598 | 0.71 | MCL1 (0.52) | SIRT1SIRT2MCL1EPHX1RECQL | |
| SCHEMBL21477523 | 0.71 | MCL1 (0.52) | SIRT1SIRT2MCL1EPHX1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |