Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573450 | 0.77 | HSD17B10 (0.40) | APEX1BLMPARP2POLBGAA | |
| SCHEMBL4573449 | 0.73 | POLB (0.40) | APEX1BLMPOLBGAACYP2C19 | |
| SCHEMBL4693552 | 0.72 | CHRM2 (0.55) | DRD2DRD3 | |
| SCHEMBL16311405 | 0.72 | SLC6A3 (0.38) | SLC6A3GAADRD2DRD3 | |
| SCHEMBL14116233 | 0.71 | SIGMAR1 (0.43) | L3MBTL1 | |
| SCHEMBL14116439 | 0.71 | SIGMAR1 (0.43) | L3MBTL1 | |
| SCHEMBL16481901 | 0.71 | POLB (0.61) | POLBGAAMEN1KMT2AL3MBTL1 | |
| SCHEMBL16481553 | 0.71 | POLB (0.61) | POLBGAAMEN1KMT2AL3MBTL1 | |
| SCHEMBL18023738 | 0.70 | PARP2 (0.40) | PARP2POLBGAAKMT2AL3MBTL1 | |
| SCHEMBL31441564 | 0.68 | TP53 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100621-A2 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | claimed |