Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 6/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589602 | 0.84 | IKBKB (0.59) | IKBKBCHUK | |
| SCHEMBL5032034 | 0.75 | IKBKB (0.58) | IKBKBCHUKMMP14 | |
| SCHEMBL5363538 | 0.74 | CYP1A2 (0.60) | HTR6HTR1AHTR1DHTR1BOPRM1 | |
| SCHEMBL5705170 | 0.74 | KDM4E (0.62) | PRMT5LTA4HPLA2G2AHTR1ASLC6A4 | |
| SCHEMBL18324811 | 0.72 | KCNH2 (0.53) | PRMT5OPRM1OPRK1OPRL1 | |
| SCHEMBL5038182 | 0.71 | IKBKB (0.61) | IKBKBCHUK | |
| SCHEMBL4589932 | 0.71 | IKBKB (0.71) | PRMT5IKBKBCHUK | |
| SCHEMBL26863407 | 0.70 | TRPM8 (0.56) | LTA4HPLA2G2AHTR1ASLC6A4HTR1D | |
| SCHEMBL4590164 | 0.69 | IKBKB (0.59) | HTR6IKBKBCHUKMMP13MMP14 | |
| Hydrochloric Acid SCHEMBL9031803 | 0.69 | OPRM1 (0.55) | HTR6LTA4HPLA2G2AHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948187-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007062318-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |