Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8867571 | 0.82 | ALDH1A1 (0.49) | PTGS1PTGS2KDM4EPOLBMAPT | |
| SCHEMBL8866347 | 0.80 | RAB9A (0.46) | PTGS1PTGS2KDM4EPOLBMAPT | |
| SCHEMBL3368294 | 0.76 | PTGS1 (0.53) | PTGS1PTGS2KDM4EPOLBSCN10A | |
| SCHEMBL23534277 | 0.74 | PTGS1 (0.48) | PTGS1PTGS2KDM4EPOLBEGLN1 | |
| SCHEMBL23534275 | 0.74 | PTGS1 (0.48) | PTGS1PTGS2KDM4EPOLBEGLN1 | |
| SCHEMBL23535036 | 0.74 | PTGS1 (0.48) | PTGS1PTGS2KDM4EPOLBEGLN1 | |
| SCHEMBL12393079 | 0.73 | PTGS1 (0.44) | PTGS1PTGS2KDM4EPOLBEGLN1 | |
| SCHEMBL21033607 | 0.73 | PTGS1 (0.53) | PTGS1PTGS2KDM4EPOLBEGLN1 | |
| SCHEMBL8607758 | 0.73 | PTGS1 (0.53) | PTGS1PTGS2KDM4EPOLBEGLN1 | |
| SCHEMBL506765 | 0.73 | P4HTM (0.41) | KDM4EMAPTLMNAKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207650-A1 | Chemical Compounds 636 | ASTRAZENECA AB (SE) | 2008-08-28 | — | — | US | disclosed |
| WO-2008084240-A1 | CHEMICAL COMPOUNDS 636 : PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207650-A1 | Chemical Compounds 636 | PDE4A, PDE3B, PDE3A | PTGS1 82/4885PTGS2 206/4885KDM4E 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.