Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 5/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14013388 | 0.87 | SCN9A (0.36) | MLNRTACR1KDM4ESMN1; SMN2RIPK1 | |
| SCHEMBL4573863 | 0.87 | SCN9A (0.36) | MLNRTACR1KDM4ESMN1; SMN2RIPK1 | |
| SCHEMBL14013327 | 0.86 | MLNR (0.36) | MLNRTACR1KDM4ESMN1; SMN2RIPK1 | |
| SCHEMBL2022959 | 0.85 | XIAP (0.40) | MLNRPARP1PARP2GRM2 | |
| SCHEMBL4574348 | 0.81 | GRM2 (0.41) | MLNRTACR1KDM4ESMN1; SMN2RIPK1 | |
| SCHEMBL4574465 | 0.77 | GRIN2D (0.48) | RIPK1 | |
| SCHEMBL14013955 | 0.76 | GRIN2D (0.37) | MLNRRIPK1GRM2KCNH2 | |
| SCHEMBL14013795 | 0.76 | MLNR (0.38) | MLNRRIPK1ALDH1A1TDP1 | |
| SCHEMBL14013797 | 0.76 | RIPK1 (0.43) | MLNRRIPK1 | |
| SCHEMBL4573901 | 0.76 | RIPK1 (0.36) | MLNRRIPK1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134035-A1 | ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008134035-A1 | ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |