Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28172901 | 0.84 | KDM4E (0.50) | CLEC4MALDH1A1PIM3PIM1HSD17B10 | |
| SCHEMBL5238691 | 0.81 | KDM4E (0.43) | PDPK1CLEC4MALDH1A1ATMMAPK1 | |
| SCHEMBL8593494 | 0.81 | PDPK1 (0.42) | PDPK1CLEC4MALDH1A1ATMMAPK1 | |
| SCHEMBL8591739 | 0.80 | CLEC4M (0.42) | PDPK1CLEC4MALDH1A1ATMMAPK1 | |
| SCHEMBL27506941 | 0.77 | PIM3 (0.45) | PDPK1CLEC4MALDH1A1ATMMAPK1 | |
| SCHEMBL27361577 | 0.75 | CTNNB1 (0.51) | ALDH1A1HSD17B10KDM4EHPGDELANE | |
| SCHEMBL8594220 | 0.74 | CLEC4M (0.38) | PDPK1CLEC4MALDH1A1ATMMAPK1 | |
| SCHEMBL3925907 | 0.74 | SLC22A6 (0.64) | ALDH1A1ATMMAPK1SLC22A6 | |
| SCHEMBL8595771 | 0.74 | ESR1 (0.52) | CLEC4MALDH1A1KDM4EHPGDAURKA | |
| SCHEMBL8595088 | 0.74 | ESR1 (0.52) | ALDH1A1HSD17B10KDM4EHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948187-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-30 | — | — | EP | disclosed |
| EP-1896014-A2 | CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007062318-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007005534-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-11 | — | — | WO | disclosed |