Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551625 | 0.77 | NPC1 (0.58) | METAP2METAP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2429096 | 0.75 | METAP2 (0.49) | METAP2METAP1SMN1; SMN2MEN1ALOX15 | |
| SCHEMBL183275 | 0.72 | METAP1 (0.60) | METAP2METAP1ENPP1NPY5R | |
| SCHEMBL9356684 | 0.72 | METAP2 (0.44) | METAP2METAP1ENPP1NPY5R | |
| SCHEMBL5828208 | 0.72 | METAP2 (0.44) | METAP2METAP1ENPP1NPC1ALDH1A1 | |
| SCHEMBL3421963 | 0.72 | METAP2 (0.44) | METAP2METAP1ENPP1NPY5R | |
| SCHEMBL5072700 | 0.72 | METAP2 (0.44) | METAP2METAP1ENPP1NPY5R | |
| SCHEMBL3811925 | 0.71 | SMN1; SMN2 (0.36) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL3426596 | 0.71 | METAP2 (0.41) | METAP2METAP1ENPP1HPGDNPY5R | |
| SCHEMBL5436671 | 0.71 | METAP2 (0.41) | METAP2METAP1ENPP1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016091916-A1 | PYRAZOLYLAMINOPURINES AS ITK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-16 | — | — | WO | disclosed |
| WO-2016091916-A1 | PYRAZOLYLAMINOPURINES AS ITK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-16 | — | — | WO | disclosed |
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008092860-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |