Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 11/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 8/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | NEK3 | P51956 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | NEK5 | Q6P3R8 | 1/20 | 0.35 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080689 | 0.92 | TBK1 (0.53) | TBK1IKBKECDC7ROCK2MAP4K4 | |
| SCHEMBL10080741 | 0.87 | TBK1 (0.61) | TBK1IKBKECDK2MAP3K14JAK2 | |
| SCHEMBL10080744 | 0.84 | TBK1 (0.54) | TBK1IKBKEMAP3K14JAK2JAK3 | |
| SCHEMBL15307921 | 0.82 | TBK1 (0.49) | TBK1IKBKEMAP3K14JAK2JAK3 | |
| SCHEMBL16667407 | 0.80 | TBK1 (0.51) | TBK1IKBKECDC7ROCK2MAP4K4 | |
| SCHEMBL10080690 | 0.77 | TBK1 (0.53) | TBK1IKBKECDC7ROCK2MAP4K4 | |
| SCHEMBL10080362 | 0.76 | TBK1 (0.53) | TBK1IKBKECDC7ROCK2MAP4K4 | |
| SCHEMBL433909 | 0.76 | TBK1 (0.53) | TBK1CDC7ROCK2MAP4K4CDK2 | |
| SCHEMBL433957 | 0.75 | TBK1 (0.63) | TBK1IKBKEROCK2CDK2GSK3B | |
| SCHEMBL16684089 | 0.74 | TBK1 (0.54) | TBK1IKBKECDK2MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595964-A1 | PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Domainex Limited (GB) | 2013-05-29 | — | — | EP | claimed |
| WO-2012010826-A1 | PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMAINEX LIMITED (GB) | 2012-01-26 | — | — | WO | claimed |
| EP-2595964-A1 | PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Domainex Limited (GB) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012010826-A1 | PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMAINEX LIMITED (GB) | 2012-01-26 | — | — | WO | disclosed |