Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.60 |
| ▸ | RET | P07949 | 3/20 | 0.60 |
| ▸ | EGFR | P00533 | 18/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 7/20 | 0.54 |
| ▸ | GAK | O14976 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.53 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.53 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.53 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947115 | 0.85 | AURKA (0.68) | KDREGFRAURKBAURKAPDGFRB | |
| SCHEMBL3948600 | 0.84 | ABCG2 (0.66) | KDRRETEGFRAURKBAURKA | |
| SCHEMBL5769764 | 0.80 | BRAF (0.51) | KDRRETEGFRAURKBAURKA | |
| SCHEMBL3947263 | 0.78 | KDR (0.72) | KDRRETEGFRAURKBAURKA | |
| SCHEMBL5767284 | 0.78 | KDR (0.47) | KDRRETEGFRAURKBAURKA | |
| SCHEMBL5768564 | 0.78 | EGFR (0.48) | KDREGFRAURKBAURKAABCG2 | |
| SCHEMBL3533221 | 0.78 | EGFR (0.80) | KDRRETEGFRCLK1ABCG2 | |
| SCHEMBL3953259 | 0.78 | KDR (0.63) | KDREGFRFLT1 | |
| SCHEMBL3947988 | 0.78 | AURKB (0.71) | KDREGFRAURKBAURKAIRAK4 | |
| Hydrochloric Acid SCHEMBL8871198 | 0.77 | EGFR (0.80) | KDRRETEGFRCLK1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885719-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006066795-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2006-06-29 | — | — | WO | disclosed |