Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 12/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767284 | 0.93 | KDR (0.47) | EGFRABL1KDRAURKBAURKA | |
| SCHEMBL5769764 | 0.85 | BRAF (0.51) | EGFRKDRAURKBAURKARAF1 | |
| SCHEMBL5765096 | 0.85 | KDR (0.48) | EGFRKDRAURKBAURKABRAF | |
| SCHEMBL4590506 | 0.78 | KDR (0.60) | EGFRKDRAURKBAURKAABCG2 | |
| SCHEMBL3949424 | 0.78 | KDR (0.61) | EGFRKDRAURKBAURKA | |
| SCHEMBL3949732 | 0.78 | KDR (0.72) | EGFRKDRAURKBAURKA | |
| SCHEMBL3949215 | 0.78 | KDR (0.60) | EGFRKDRAURKBAURKA | |
| SCHEMBL3947988 | 0.77 | AURKB (0.71) | EGFRKDRAURKBAURKA | |
| SCHEMBL3949004 | 0.76 | KDR (0.73) | EGFRKDRAURKBAURKA | |
| SCHEMBL3953271 | 0.76 | KDR (0.73) | EGFRKDRAURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1674467-A1 | 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors | 4SC AG (DE) | 2006-06-28 | — | — | EP | disclosed |