Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 5/20 | 0.46 |
| ▸ | ACACB | O00763 | 4/20 | 0.45 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590665 | 1.00 | GPR119 (0.47) | GPR119MAP4K4FAAHACACBSUV39H2 | |
| SCHEMBL16580717 | 0.85 | MAP4K4 (0.55) | GPR119MAP4K4FAAHSUV39H2NR1H2 | |
| SCHEMBL5465391 | 0.85 | MAP4K4 (0.55) | GPR119MAP4K4FAAHSUV39H2NR1H2 | |
| SCHEMBL17958723 | 0.85 | MAP4K4 (0.55) | GPR119MAP4K4FAAHSUV39H2NR1H2 | |
| SCHEMBL13279273 | 0.84 | GPR119 (0.51) | GPR119MAP4K4FAAHSUV39H2NR1H2 | |
| SCHEMBL15441723 | 0.84 | GPR119 (0.51) | GPR119MAP4K4FAAHSUV39H2NR1H2 | |
| SCHEMBL4589989 | 0.84 | ACACB (0.49) | FAAHACACB | |
| SCHEMBL31181041 | 0.84 | GPR119 (0.51) | GPR119MAP4K4FAAHSUV39H2NR1H2 | |
| SCHEMBL15378173 | 0.83 | FAAH (0.55) | GPR119MAP4K4FAAHSUV39H2NR1H2 | |
| SCHEMBL20139215 | 0.83 | FAAH (0.55) | GPR119MAP4K4FAAHSUV39H2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |