Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.56 |
| ▸ | EGFR | P00533 | 6/20 | 0.56 |
| ▸ | BRAF | P15056 | 6/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589861 | 0.87 | KDR (0.55) | KDREGFRBRAFFLT4RAF1 | |
| SCHEMBL3948976 | 0.87 | BRAF (0.60) | KDREGFRBRAFEPHA2CA2 | |
| SCHEMBL4590535 | 0.86 | KDR (0.52) | KDREGFREPHA2FLT1FLT4 | |
| SCHEMBL4590707 | 0.86 | KDR (0.46) | KDREGFRBRAFFLT1FLT4 | |
| SCHEMBL3948346 | 0.86 | EGFR (0.60) | KDREGFRBRAFCA2CA9 | |
| SCHEMBL4590825 | 0.85 | AURKA (0.53) | KDREGFRBRAFKITFGFR1 | |
| SCHEMBL3947811 | 0.85 | KDR (0.59) | KDREGFRBRAFCA2CA9 | |
| SCHEMBL3947634 | 0.85 | KDR (0.72) | KDREGFRBRAFFLT1FLT4 | |
| SCHEMBL3945598 | 0.85 | KDR (0.72) | KDREGFRBRAFFLT1FLT4 | |
| SCHEMBL3953829 | 0.84 | KDR (0.71) | KDREGFRBRAFFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885719-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006066795-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2006-06-29 | — | — | WO | disclosed |