Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.55 |
| ▸ | AURKA | O14965 | 4/20 | 0.52 |
| ▸ | FLT4 | P35916 | 3/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 7/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CSK | P41240 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590825 | 0.92 | AURKA (0.53) | KDRAURKAEGFRSRCAURKB | |
| SCHEMBL4590535 | 0.89 | KDR (0.52) | KDRAURKAFLT4PDGFRBEGFR | |
| SCHEMBL4590707 | 0.89 | KDR (0.46) | KDRFLT4EGFRSRCAURKB | |
| SCHEMBL4590725 | 0.87 | KDR (0.56) | KDRFLT4RAF1EGFRFGFR1 | |
| SCHEMBL3946532 | 0.86 | KDR (0.74) | KDRFLT4PDGFRBRAF1EGFR | |
| SCHEMBL3953837 | 0.85 | KDR (0.62) | KDRAURKAFLT4PDGFRBRAF1 | |
| SCHEMBL3947313 | 0.84 | KDR (0.62) | KDRAURKAFLT4PDGFRBRAF1 | |
| SCHEMBL3947459 | 0.84 | KDR (0.61) | KDRAURKAFLT4PDGFRBRAF1 | |
| SCHEMBL3947281 | 0.83 | EGFR (0.69) | KDRAURKAFLT4PDGFRBEGFR | |
| SCHEMBL3949805 | 0.82 | KDR (0.70) | KDRAURKAEGFRSRCAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885719-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006066795-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2006-06-29 | — | — | WO | disclosed |