Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 12/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 10/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CSK | P41240 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589861 | 0.92 | KDR (0.55) | AURKAEGFRKDRSRCFGFR2 | |
| SCHEMBL4590707 | 0.87 | KDR (0.46) | EGFRKDRSRCFGFR2IGF1R | |
| SCHEMBL4590535 | 0.86 | KDR (0.52) | AURKAEGFRKDRSRCFGFR2 | |
| SCHEMBL4590725 | 0.85 | KDR (0.56) | EGFRKDRFGFR1KITBRAF | |
| SCHEMBL3954388 | 0.85 | EGFR (0.59) | AURKAEGFRKDRAURKBBRAF | |
| SCHEMBL3948583 | 0.79 | EGFR (0.66) | AURKAEGFRKDRAURKBERBB2 | |
| SCHEMBL3947263 | 0.77 | KDR (0.72) | AURKAEGFRKDRAURKBHDAC6 | |
| SCHEMBL3946532 | 0.77 | KDR (0.74) | EGFRKDRSRCHDAC6KIT | |
| SCHEMBL3953837 | 0.77 | KDR (0.62) | AURKAEGFRKDRSRCKIT | |
| SCHEMBL3947784 | 0.76 | EGFR (0.61) | AURKAEGFRKDRSRCAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885719-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006066795-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2006-06-29 | — | — | WO | disclosed |